Effect of tolbutamide on the respiration of heart muscle mitochondria.
نویسندگان
چکیده
Tolbutamide, one of the hypoglycemic sulphonylurea drugs was fcund to decrease the respiratory control index of beef heart mitochondria as well as that of rat liver mitochondria. The effect of the drug on beef heart mitochondria was more pronounced than on liver mitochondria in the r an ge of concentrations of 30-80 mg% . It was of interest to find that DNP release of mitochondrial respiration was not observed after the addition of 100 mg% tolbutamide. These findings were discussed in relation to the side; effect of this drug.
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عنوان ژورنال:
- Nagoya journal of medical science
دوره 35 2 شماره
صفحات -
تاریخ انتشار 1973